SC 58125
CAS No. 162054-19-5
SC 58125 ( —— )
Catalog No. M22961 CAS No. 162054-19-5
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor,?with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesicSC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 50 | In Stock |
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10MG | 87 | In Stock |
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25MG | 192 | In Stock |
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50MG | 311 | In Stock |
|
100MG | 502 | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameSC 58125
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NoteResearch use only, not for human use.
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Brief DescriptionSC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor,?with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesicSC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?
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DescriptionSC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor,?with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesicSC-58125 treatment on the growth of human colon carcinoma cells in nude mice.?Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth.?Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days.?SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G(2)/M transition.?Accordingly, p34(cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX-2
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Research Area——
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Indication——
Chemical Information
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CAS Number162054-19-5
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Formula Weight384.35
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Molecular FormulaC17H12F4N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESFC(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(F)C=C3)=C1)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Williams C S , Sheng H , Brockman J A , et al. A Cyclooxygenase-2 Inhibitor (SC-58125) Blocks Growth of Established Human Colon Cancer Xenografts[J]. Neoplasia (New York, N.Y.), 2001, 3(5).
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